The etiology and pathogenesis of the classification of postpartum infectious (septic) disease-2

Pathogenic staphylococci are less invasive compared with streptococci. Due to necrotizing effect, have pathogenic staphylococci, and in part to their ability to coagulate plasma relatively quickly come thrombosis lymph and fixing staphylococci in inflammatory foci.
Thus, when a staph infection are conditions conducive localization of the pathological process, but at the same time the penetration of antibiotics in the area of inflammation.
With substantial microbial virulence of infection may not occur or be inadequate. In the first case, the disease will occur by the type of acute sepsis, the second — the disease for a longer time-consuming, while from time to time will be dissemination of microbial infectious focus.
From the properties of microbial virulence along with significant importance for their resistance to the action of modern antibiotics and especially antibiotics. Currently, there is increase in the number of antibiotic-resistant strains of bacteria. This situation is largely due to the action of antibiotics as a factor in selection. The use of antibiotics leads to the death of sensitized germs and bacteria breeding, has a natural, natural, or acquired in the course of resistance mutations. Resistance can also develop as a result of the transfer of sustainability, usually multiple, from resistant bacteria sensitive to the exchange of genetic material containing the determinants of sustainability. Transfer factor is resistance among gram-negative bacteria, mainly Escherichia coli by conjugation of staphylococci — by transduction with phages.
You need to specify that in the whole organism buildup of resistant strains deficient concentration of antibiotics contributes to the site of infection, often associated with the use of small amounts of drugs or late onset of treatment, when it emerged anatomical changes affecting the flow of antibiotics in infectious focus. The selection of resistant organisms and the possible long-term use of high doses of some antibiotics — from selection of individual surviving resistant pathogens. It follows that it is necessary to use antibiotics in a sufficiently high dose, long-term treatment is necessary to change them (using drugs with different mechanisms of action).
Over the past few years has changed the composition of agents postpartum infection. Important role in this respect was played by antibiotics as a factor in selection. Currently, among the agents of puerperal infection dominates aureus, was not only insensitive to antibiotics, but also has the property easily develop resistance to them.
Streptococcus, that prior to the introduction of antibiotics in the practice more prevalent in modern conditions are relatively rare. This is because most pathogenic group A streptococci highly susceptible to penicillin, which is bactericidal effect on them, and they almost become resistant to the antibiotic. Streptococci of other groups, except for group A streptococci (enterococci), is also sensitive to penicillin.
Reducing the frequency polymicrobial infections, which is celebrated today, largely due to the influence of antibiotics on microbial associations — saving resistant microbes to antibiotics and elimination sensitized bacteria (including streptococci).

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