Sulfa drugs

Sulfa drugs — Derivatives of sulfanilic acid, which have antimicrobial properties.
Sulfa drugs have a broad spectrum of antimicrobial action. They have a bacteriostatic effect against streptococci, staphylococci, pneumococci, enterococci, meningococci, gonococci, Escherichia coli, sticks dysentery, typhoid, protozoa (malaria parasite and Toxoplasma), the major viruses (trachoma, psittacosis, etc.), some actinomycetes, cholera vibrio, etc.
Antimicrobial effect of sulfa drugs is mainly due to a violation of the process of obtaining the microbes for their development of growth factors — folic acid and other substances in the molecule include para-aminobenzoic acid.
In their ability to be absorbed and excreted sulfa drugs are divided into three groups: 1) is rapidly absorbed and rapidly excreted by the kidneys (see norsulfazola, Streptocide, sulphadimezin Sulfazin, sulphation, Urosulfan, etazol etc.), 2) a long-acting (see sulfapiridazina, Sulfadimethoxine) is rapidly absorbed and slowly released from the body, which allows you to assign them one time a day, and 3) is poorly absorbed from the gastrointestinal tract (see Disulformin, sulginom, Ftazin, Ftalazol). Due to the fact that the sulfa drugs a high concentration in the gut, they are shown enteritis, colitis, bacillary dysentery.
Sulfa drugs used for angina, pneumonia, streptococcal and staphylococcal sepsis, meningitis, acute intestinal infections, pustular skin lesions, inflammation in the urinary tract, ornithosis, trachoma, deep mycosis, and others, as well as for the prevention of complications during surgery.
Some sulfonamides used as a solution for parenteral administration, as well as for local use in the solutions, powders, ointments, liniments, suppositories.
When treating sulfanilamidnymi drugs may experience side effects such as nausea, vomiting, headache, dizziness, skin rash, drug fever, leucopenia. The development of side effects reduce the dose, if necessary, stop taking the drug. Relatively often have impaired renal function. Due to the poor solubility of sulfonamides and particularly their acetylated products may fall in the kidneys in the form of crystals (crystalluria). To prevent this complication designate a rich alkaline water. There may be a development of resistance to sulfonamide drugs.
Contraindication to the use of a hypersensitivity to sulfonamide drugs. In diseases of the hematopoietic system, renal failure, liver disease, cardiac decompensation sulfa drugs  Use with caution.

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